Gene Variant Detail

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Gene RAD51C
Variant A279V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C A279V does not lie within any known functional domains of the Rad51c protein (UniProt.org). A279V rescues survival of Rad51c-null cells in culture, however, results in decreased interaction with Rad51b, Rad51d, and Xrcc3 in a yeast assay and reduced homologous recombination activity compared to wild-type Rad51c in cultured cells (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C A279V

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Transcript NM_058216.3
gDNA chr17:g.58709989C>T
cDNA c.836C>T
Protein p.A279V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58709989C>T c.836C>T p.A279V RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58709989C>T c.836C>T p.A279V RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58709989C>T c.836C>T p.A279V RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58709989C>T c.836C>T p.A279V RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58709989C>T c.836C>T p.A279V RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58709989C>T c.836C>T p.A279V RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References