RAD51C D108Y
Gene Variant Detail

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Gene RAD51C
Variant D108Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C D108Y lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). D108Y results in interaction with Rad51b, Rad51d, and Xrcc3 similar to wild-type Rac51c in a yeast assay, and retains functional homologous recombination activity and rescues survival in Rad51c-null cells in culture (PMID: 36099300), however, the genomic change (c.322G>T) leads to decreased survival in a high-throughput cell culture assay (PMID: 39299233), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C D108Y

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Transcript NM_058216.3
gDNA chr17:g.58695107G>T
cDNA c.322G>T
Protein p.D108Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695107G>T c.322G>T p.D108Y RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References