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Gene RAD51C
Variant I144T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RAD51C I144T does not lie within any known functional domains of the Rad51c protein (UniProt.org). I144T is conflicting as it demonstrates reduced homologous recombination activity in one cell line, but proficient activity in another, rescues survival in Rad51c-null cells in culture but results in variable interaction with Rad51b, Rad51d, and Xrcc3 in a yeast assay (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C I144T

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Transcript NM_058216.3
gDNA chr17:g.58696719T>C
cDNA c.431T>C
Protein p.I144T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.5 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58696719T>C c.431T>C p.I144T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
RAD51C I144T unknown