Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | RAD51C |
Variant | L262V |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | RAD51C L262V does not lie within any known functional domains of the Rad51c protein (UniProt.org). L262V retains binding with Rad51b and Xrcc3, but results in variable interaction with Rad51d in a yeast assay (PMID: 36099300), and therefore, its effect on Rad51c protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
RAD51C mutant RAD51C L262V |
Transcript | NM_058216.3 |
gDNA | chr17:g.58709937T>G |
cDNA | c.784T>G |
Protein | p.L262V |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_006722002.5 | chr17:g.58709937T>G | c.784T>G | p.L262V | RefSeq | GRCh38/hg38 |
NM_058216.3 | chr17:g.58709937T>G | c.784T>G | p.L262V | RefSeq | GRCh38/hg38 |
XM_006722002.4 | chr17:g.58709937T>G | c.784T>G | p.L262V | RefSeq | GRCh38/hg38 |
XM_006722001.4 | chr17:g.58709937T>G | c.784T>G | p.L262V | RefSeq | GRCh38/hg38 |
NM_058216.2 | chr17:g.58709937T>G | c.784T>G | p.L262V | RefSeq | GRCh38/hg38 |
XM_006722001.5 | chr17:g.58709937T>G | c.784T>G | p.L262V | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|