RAD51C T336P
Gene Variant Detail

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Gene RAD51C
Variant T336P
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions RAD51C T336P does not lie within any known functional domains of the Rad51c protein (UniProt.org). T336P retains binding with Rad51b and Xrcc3 (PMID: 36099300, PMID: 37253112), but results in variable interaction with Rad51d in a yeast assay (PMID: 36099300), demonstrates lack of binding to Rad51d and Xrcc2 and results in decreased Rad51c homology-directed repair (HDR) activity compared to wild-type Rad51c in culture (PMID: 37253112), and therefore, is predicted to lead to a loss of Rad51c protein function.
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C T336P

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Transcript NM_058216.3
gDNA chr17:g.58732524A>C
cDNA c.1006A>C
Protein p.T336P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.3 chr17:g.58732524A>C c.1006A>C p.T336P RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58732524A>C c.1006A>C p.T336P RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
RAD51C T336P loss of function - predicted