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Gene TP53
Variant H168P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions TP53 H168P lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). H168P results in subcellular localization similar to wild-type in Tp53-null cells, but leads to increased cellular growth rate, decreased transactivation of Tp53 target genes, and reduced apoptotic function in cell culture (PMID: 23246812).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 H168P

TP53 mutant TP53 inact mut TP53 H168P

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Transcript NM_000546.6
gDNA chr17:g.7675109T>G
cDNA c.503A>C
Protein p.H168P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.5 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675109T>G c.503A>C p.H168P RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References