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Gene TP53
Variant E198_G199del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions TP53 E198_G199del results in the deletion of two amino acids in the DNA-binding domain of the Tp53 protein from amino acids 198 to 199 (PMID: 22713868). E198_G199del results in increased cytoplasmic localization in Tp53-null cells, increased cellular growth rate, decreased transactivation of Tp53 target genes, and reduced apoptotic function in cell culture (PMID: 23246812).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon6 TP53 E198_G199del

TP53 mutant TP53 inact mut TP53 E198_G199del

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Transcript NM_000546.6
gDNA chr17:g.7674934_7674939delTCCTTC
cDNA c.592_597delGAAGGA
Protein p.E198_G199delEG
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407271.1 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199del RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001276697.3 chr17:g.7670636_7670641delTCCTTC c.592_597delAAGGAG p.K198_E199delKE RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199del RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199del RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7673535_7673540delCTGAAG c.592_597delCTTCAG p.L198_Q199delLQ RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199del RefSeq GRCh38/hg38
NM_001126117.2 chr17:g.7673535_7673540delCTGAAG c.592_597delCTTCAG p.L198_Q199delLQ RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674934_7674939delTCCTTC c.592_597delGAAGGA p.E198_G199delEG RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38
NM_001126116.2 chr17:g.7673535_7673540delCTGAAG c.592_597delCTTCAG p.L198_Q199delLQ RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7674249_7674254delACACAT c.593_598delTGTGTA p.M198_C199delMC RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References