Gene Variant Detail

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Gene TP53
Variant H233_Y234del
Impact List deletion
Protein Effect loss of function
Gene Variant Descriptions TP53 H233_Y234del results in the deletion of two amino acids in the DNA-binding domain of the Tp53 protein from amino acids 233 to 234 (PMID: 22713868). H233_Y234del results in increased cytoplasmic localization in Tp53-null cells, increased cellular growth rate, decreased transactivation of Tp53 target genes, and reduced apoptotic function in cell culture (PMID: 23246812).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 H233_Y234del

TP53 mutant TP53 inact mut TP53 H233_Y234del

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Transcript NM_000546.6
gDNA chr17:g.7674262_7674267delTAGTGG
cDNA c.697_702delCACTAC
Protein p.H233_Y234delHY
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234del RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234del RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7670611_7670616delGGAGTG c.697_702delCACTCC p.H233_S234delHS RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001276697.3 chr17:g.7669615_7669620delTGAGTC c.698_703delCAGACT p.S233_D234delSD RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234del RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234delHY RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674262_7674267delTAGTGG c.697_702delCACTAC p.H233_Y234del RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673801_7673806delACGCAC c.699_704delGCGTGT p.R234_V235delRV RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References