Gene Variant Detail

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Gene FLT3
Variant M837_D839delinsGRH
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FLT3 M837_D839delinsGRH results in a deletion of three amino acids in the protein kinase domain of the Flt3 protein from amino acids 837 to 839, combined with the insertion of three amino acids at the same site (UniProt.org). M837_D839delinsGRH has been associated with drug resistance when co-occurring with FLT3 internal tandem duplication (FLT3-ITD) (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 M837_D839delinsGRH

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Transcript NM_004119.3
gDNA chr13:g.28018491_28018499delinsATGCCTACC
cDNA c.2509_2517delinsGGTAGGCAT
Protein p.M837_D839delinsGRH
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018491_28018499delinsATGCCTACC c.2509_2517delinsGGTAGGCAT p.M837_D839delinsGRH RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018491_28018499delinsATGCCTACC c.2509_2517delinsGGTAGGCAT p.M837_D839delinsGRH RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
FLT3 M837_D839delinsGRH unknown
FLT3 exon 14 ins FLT3 M837_D839delinsGRH