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Gene FLT3
Variant M837_D839delinsGRH
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FLT3 M837_D839delinsGRH results in a deletion of three amino acids in the protein kinase domain of the Flt3 protein from amino acids 837 to 839, combined with the insertion of three amino acids at the same site (UniProt.org). M837_D839delinsGRH has been associated with drug resistance when co-occurring with FLT3 internal tandem duplication (FLT3-ITD) (PMID: 25847190), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon20 FLT3 M837_D839delinsGRH

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Transcript NM_004119.3
gDNA chr13:g.28018491_28018499delinsATGCCTACC
cDNA c.2509_2517delinsGGTAGGCAT
Protein p.M837_D839delinsGRH
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28018491_28018499delinsATGCCTACC c.2509_2517delinsGGTAGGCAT p.M837_D839delinsGRH RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018491_28018499delinsATGCCTACC c.2509_2517delinsGGTAGGCAT p.M837_D839delinsGRH RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References