Gene Variant Detail

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Gene PIK3CA
Variant A1066V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA A1066V does not lie within any known functional domains of the Pik3ca protein (UniProt.org). A1066V results in Akt phosphorylation levels similar to wild-type Pik3ca, but results in increased anchorage-independent colony formation and cell motility in conditions without growth factor in cell culture (PMID: 22430209), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA A1066V

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Transcript NM_006218.4
gDNA chr3:g.179234354C>T
cDNA c.3197C>T
Protein p.A1066V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
PIK3CA A1066V unknown
FGFR3 R248C PIK3CA A1066V