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Gene TP53
Variant L257V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 L257V lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). L257V has been identified in sequencing studies (PMID: 33569316, PMID: 33251333, PMID: 31922633), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 L257V

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Transcript NM_000546.6
gDNA chr17:g.7674194G>C
cDNA c.769C>G
Protein p.L257V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674194G>C c.769C>G p.L257V RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
TP53 L257V unknown