FGFR3 V553L
Gene Variant Detail

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Gene FGFR3
Variant V553L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR3 V553L lies within the protein kinase domain (UniProt.org). V553L has been identified in the scientific literature (PMID: 37377403), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Jul 2025).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 V553L

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Transcript NM_000142.5
gDNA chr4:g.1805761G>C
cDNA c.1657G>C
Protein p.V553L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.5 chr4:g.1805761G>C c.1657G>C p.V553L RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1805761G>C c.1657G>C p.V553L RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1805761G>C c.1657G>C p.V553L RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1805761G>C c.1657G>C p.V553L RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1805761G>C c.1657G>C p.V553L RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1805761G>C c.1657G>C p.V553L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References