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Gene TP53
Variant D21fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 D21fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 21 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). D21fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of D21 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon2 TP53 D21fs

TP53 mutant TP53 inact mut TP53 D21fs

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Transcript NM_000546.6
gDNA chr17:g.(7676534_7676535)
cDNA c.(61_60)
Protein p.D21fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7676534_7676535) c.(61_60) p.D21fs RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries