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Gene TP53
Variant S241fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 S241fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 241 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). S241fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of S241 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 S241fs

TP53 mutant TP53 inact mut TP53 S241fs

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Transcript NM_000546.6
gDNA chr17:g.(7674242_7674243)
cDNA c.(721_720)
Protein p.S241fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126113.2 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7674242_7674243) c.(721_720) p.S241fs RefSeq GRCh38/hg38

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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries