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Gene PTEN
Variant N117fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN N117fs results in a change in the amino acid sequence of the Pten protein beginning at 117 of 403, likely resulting in premature truncation of the functional protein (UniProt.org). N117fs has not been characterized, however, due to the effects of other truncation mutations downstream of N117 (PMID: 10468583), is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN N117fs

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No Variant Reference Transcript is Available.
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.(87933107_87933108) c.(349_348) p.N117fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PTEN N117fs loss of function - predicted Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor