PTEN S338fs
Gene Variant Detail

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Gene PTEN
Variant S338fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions PTEN S338fs results in a change in the amino acid sequence of the Pten protein beginning at 338 of 403, likely resulting in premature truncation of the functional protein (UniProt.org). S338fs has been identified in the scientific literature (PMID: 30301868), but has not been biochemically characterized and therefore, its effect on Pten protein function is unknown (PubMed, Mar 2026).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN S338fs

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Transcript NM_000314.8
gDNA chr10:g.(87961103_87961104)
cDNA c.(1012_1011)
Protein p.S338fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.(87961103_87961104) c.(1012_1011) p.S338fs RefSeq GRCh38/hg38
NM_000314.8 chr10:g.(87961103_87961104) c.(1012_1011) p.S338fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References