RAD51C R237*
Gene Variant Detail

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Gene RAD51C
Variant R237*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions RAD51C R237* results in a premature truncation of the Rad51c protein at amino acid 237 of 376 (UniProt.org). R237* has been identified in the scientific literature (PMID: 37129948, PMID: 36451132, PMID: 40282418), but has not been biochemically characterized and therefore, its effect on Rad51c protein function is unknown (PubMed, Jun 2025).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C R237*

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Transcript NM_058216.3
gDNA chr17:g.58709862C>T
cDNA c.709C>T
Protein p.R237*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_058216.2 chr17:g.58709862C>T c.709C>T p.R237* RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58709862C>T c.709C>T p.R237* RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58709862C>T c.709C>T p.R237* RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58709862C>T c.709C>T p.R237* RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58709862C>T c.709C>T p.R237* RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58709862C>T c.709C>T p.R237* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C R237* gastroesophageal adenocarcinoma predicted - sensitive Cisplatin + Fluorouracil + Trastuzumab Case Reports/Case Series Actionable In a retrospective analysis, treatment with the combination of Herceptin (trastuzumab), Platinol (cisplatin), and Adrucil (fluorouracil) resulted in a partial response and a progression-free survival of 13.0 months in a patient with gastroesophageal adenocarcinoma harboring RAD51C R237* (PMID: 37129948). 37129948