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Gene TET2
Variant D162fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TET2 D162fs results in a change in the amino acid sequence of the Tet2 protein beginning at aa 162 of 2002, likely resulting in premature truncation of the functional protein (UniProt.org). D162fs has not been characterized, however, due to the effects of other truncation mutations downstream of D162 (PMID: 24994606), is predicted to lead to a loss of Tet2 protein function.
Associated Drug Resistance
Category Variants Paths

TET2 mutant TET2 inact mut TET2 D162fs

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Transcript NM_001127208.3
gDNA chr4:g.(105234425_105234426)
cDNA c.(484_483)
Protein p.D162fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_017628.4 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
NM_001127208.2 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_006714242.3 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_024454102.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_024454102.2 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_047415843.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
NM_001127208.3 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_047415840.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_017008319.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_047415842.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
NM_017628.4 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_005263082.4 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_017008319.2 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_047415841.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_024454103.2 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_006714242.4 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_047415839.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_005263082.3 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38
XM_024454103.1 chr4:g.(105234425_105234426) c.(484_483) p.D162fs RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References