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Gene RAD51C
Variant V140E
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C V140E does not lie within any known functional domains of the Rad51c protein (UniProt.org). V140E results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, decreased Rad51 foci formation, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C V140E

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Transcript NM_058216.3
gDNA chr17:g.58696707T>A
cDNA c.419T>A
Protein p.V140E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58696707T>A c.419T>A p.V140E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RAD51C V140E Advanced Solid Tumor sensitive Cisplatin Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C V140E sensitized RAD51C-deficient cells to Platinol (cisplatin) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112
RAD51C V140E Advanced Solid Tumor sensitive Olaparib Preclinical - Cell culture Actionable In a preclinical study, the expression of RAD51C V140E sensitized RAD51C-deficient cells to Lynparza (olaparib) treatment in culture, resulting in decreased cell proliferation (PMID: 37253112). 37253112