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Gene RAD51C
Variant G114V
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C G114V lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). G114V results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C G114V

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Transcript NM_058216.3
gDNA chr17:g.58695126G>T
cDNA c.341G>T
Protein p.G114V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002876.3 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695126G>T c.341G>T p.G114V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RAD51C G114V loss of function Olaparib