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Gene RAD51C
Variant A279P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C A279P does not lie within any known functional domains of the Rad51c protein (UniProt.org). A279P results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C A279P

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Transcript NM_058216.3
gDNA chr17:g.58709988G>C
cDNA c.835G>C
Protein p.A279P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722002.4 chr17:g.58709988G>C c.835G>C p.A279P RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58709988G>C c.835G>C p.A279P RefSeq GRCh38/hg38
XM_006722001.4 chr17:g.58709988G>C c.835G>C p.A279P RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58709988G>C c.835G>C p.A279P RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58709988G>C c.835G>C p.A279P RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58709988G>C c.835G>C p.A279P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries