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Gene RAD51C
Variant T102I
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions RAD51C T102I lies within the region required for Holliday junction resolution activity and the Rad51b, Rad51d, and Xrcc3-interacting region of the Rad51c protein (UniProt.org). T102I results in loss of interaction with Xrcc2, Xrcc3, and Rad51d, and reduced homology-directed DNA repair activity compared to wild-type Rad51c in culture (PMID: 37253112).
Associated Drug Resistance
Category Variants Paths

RAD51C mutant RAD51C inact mut RAD51C T102I

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Transcript NM_058216.3
gDNA chr17:g.58695090C>T
cDNA c.305C>T
Protein p.T102I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006722001.4 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
XM_047436505.1 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
NM_058216.2 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
NM_058216.3 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
NM_002876.4 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
NM_002876.3 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
XM_006722002.4 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
XM_006722001.5 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38
XM_006722002.5 chr17:g.58695090C>T c.305C>T p.T102I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries