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Gene PIK3CA
Variant D350H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA D350H lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). D350H has been identified in the scientific literature (PMID: 37318638, PMID: 28912153, PMID: 33203919), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon5 PIK3CA D350H

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Transcript NM_006218.4
gDNA chr3:g.179203778G>C
cDNA c.1048G>C
Protein p.D350H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.4 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
PIK3CA D350H unknown