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Gene PIK3CA
Variant D350H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA D350H lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). D350H has been identified in the scientific literature (PMID: 37318638, PMID: 28912153, PMID: 33203919), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon5 PIK3CA D350H

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Transcript NM_006218.4
gDNA chr3:g.179203778G>C
cDNA c.1048G>C
Protein p.D350H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179203778G>C c.1048G>C p.D350H RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References