KMT2A T1061fs - Gene Variant Detail

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Gene KMT2A
Variant T1061fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions KMT2A T1061fs results in a change in the amino acid sequence of the Kmt2a protein beginning at aa 1061 of 3969, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), T1061fs is predicted to lead to a loss of Kmt2a protein function.
Associated Drug Resistance
Category Variants Paths

KMT2A mutant KMT2A inact mut KMT2A T1061fs

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Transcript NM_005933.4
gDNA chr11:g.(118476828_118476829)
cDNA c.(3181_3180)
Protein p.T1061fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005933.3 chr11:g.(118476828_118476829) c.(3181_3180) p.T1061fs RefSeq GRCh38/hg38
NM_001197104.2 chr11:g.(118476828_118476829) c.(3181_3180) p.T1061fs RefSeq GRCh38/hg38
NM_005933.4 chr11:g.(118476828_118476829) c.(3181_3180) p.T1061fs RefSeq GRCh38/hg38
NM_001197104.1 chr11:g.(118476828_118476829) c.(3181_3180) p.T1061fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References