Gene Variant Detail

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Gene TP53
Variant A88fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions TP53 A88fs results in a change in the amino acid sequence of the Tp53 protein beginning at aa 88 of 393, likely resulting in premature truncation of the functional protein (UniProt.org). A88fs has not been biochemically characterized however, due to the effects of truncation mutations downstream of A88 (PMID: 31081129, PMID: 34045312), is predicted to lead to a loss of Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon4 TP53 A88fs

TP53 mutant TP53 inact mut TP53 A88fs

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Transcript NM_000546.6
gDNA chr17:g.(7676107_7676108)
cDNA c.(262_261)
Protein p.A88fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001126114.3 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_000546.6 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_000546.5 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.(7676107_7676108) c.(262_261) p.A88fs RefSeq GRCh38/hg38

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Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries