ROS1 E2071K
Gene Variant Detail

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Gene ROS1
Variant E2071K
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions ROS1 E2071K lies within the protein kinase domain of the Ros1 protein (UniProt.org). E2071K results in increased colony formation and tumor formation that is not statistically significant relative to wild-type Ros1 and increased Ros1 phosphorylation in culture (PMID: 37587872), and therefore, is predicted to lead to a gain of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 act mut ROS1 E2071K

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Transcript NM_002944.2
gDNA chr6:g.117311042C>T
cDNA c.6211G>A
Protein p.E2071K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117311042C>T c.6211G>A p.E2071K RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References