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Gene ROS1
Variant D2113Y
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions ROS1 D2113Y lies within the protein kinase domain of the Ros1 protein (UniProt.org). D2113Y results in decreased Ros1 phosphorylation in culture (PMID: 37587872), and therefore, is predicted to lead to a loss of Ros1 protein function.
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 inact mut ROS1 D2113Y

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Transcript NM_002944.2
gDNA chr6:g.117310178C>A
cDNA c.6337G>T
Protein p.D2113Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.2 chr6:g.117310178C>A c.6337G>T p.D2113Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References