FLT3 K614_G617del
Gene Variant Detail

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Gene FLT3
Variant K614_G617del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 K614_G617del results in the deletion of four amino acids in the protein kinase domain of the Flt3 protein from amino acids 614 to 617 (UniProt.org). K614_G617del results in increased Flt3 phosphorylation in culture (PMID: 37246158), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 K614_G617del

FLT3 mutant FLT3 exon15 FLT3 K614_G617del

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Transcript NM_004119.2
gDNA chr13:g.28033978_28033989del12
cDNA c.1840_1851del12
Protein p.K614_G617del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28033978_28033989del12 c.1840_1851del12 p.K614_G617del RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 K614_G617del hematologic cancer predicted - sensitive Quizartinib Preclinical - Biochemical Actionable In a preclinical study, Vanflyta (quizartinib) inhibited Flt3 phosphorylation in cells expressing FLT3 K614_G617del in culture (PMID: 37246158). 37246158
FLT3 K614_G617del hematologic cancer predicted - sensitive Sorafenib Preclinical - Biochemical Actionable In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation in cells expressing FLT3 K614_G617del in culture (PMID: 37246158). 37246158