FLT3 S941_F942insRVS
Gene Variant Detail

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Gene FLT3
Variant S941_F942insRVS
Impact List insertion
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 S941_F942insRVS results in the insertion of three amino acids in the protein kinase domain of the Flt3 protein between amino acids 941 and 942 (UniProt.org). S941_F942insRVS results in increased Flt3 phosphorylation in culture (PMID: 37246158), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 S941_F942insRVS

FLT3 mutant FLT3 exon23 FLT3 S941_F942insRVS

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Transcript NM_004119.2
gDNA chr13:g.28014487_28014488insGCTTACCCT
cDNA c.2823_2824insAGGGTAAGC
Protein p.S941_F942insRVS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28014487_28014488insGCTTACCCT c.2823_2824insAGGGTAAGC p.S941_F942insRVS RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 S941_F942insRVS hematologic cancer predicted - sensitive Quizartinib Preclinical - Biochemical Actionable In a preclinical study, Vanflyta (quizartinib) inhibited Flt3 phosphorylation in cells expressing FLT3 S941_F942insRVS in culture (PMID: 37246158). 37246158
FLT3 S941_F942insRVS hematologic cancer predicted - sensitive Sorafenib Preclinical - Biochemical Actionable In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation in cells expressing FLT3 S941_F942insRVS in culture (PMID: 37246158). 37246158