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FLT3 Y591* - Gene Variant Detail

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Gene FLT3
Variant Y591*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions FLT3 Y591* results in a premature truncation of the Flt3 protein at amino acid 591 of 993 (UniProt.org). Y591* results in loss of kinase activity in culture (PMID: 37246158), and therefore, is predicted to lead to a loss of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 Y591*

FLT3 mutant FLT3 inact mut FLT3 Y591*

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Transcript NM_004119.2
gDNA chr13:g.28034146G>T
cDNA c.1773C>A
Protein p.Y591*
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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