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Gene FLT3
Variant Q577_Y589delinsPSD
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FLT3 Q577_Y589delinsPSD results in a deletion of 13 amino acids in the juxtamembrane domain of the Flt3 protein from amino acids 577 to 589, combined with the insertion of three amino acids at the same site (PMID: 37246158). Q577_Y589delinsPSD results in Flt3 phosphorylation similar to wild-type Flt3 in culture (PMID: 37246158), but has not been fully biochemically characterized and therefore, its effect on Flt3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 Q577_Y589delinsPSD

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Transcript NM_004119.2
gDNA chr13:g.28034152_28034190delinsGTCGCTAGG
cDNA c.1729_1767delinsCCTAGCGAC
Protein p.Q577_Y589delinsPSD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28034152_28034190delinsGTCGCTAGG c.1729_1767delinsCCTAGCGAC p.Q577_Y589delinsPSD RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 Q577_Y589delinsPSD hematologic cancer predicted - sensitive Quizartinib Preclinical - Biochemical Actionable In a preclinical study, Vanflyta (quizartinib) inhibited Flt3 phosphorylation in cells expressing FLT3 Q577_Y589delinsPSD in culture (PMID: 37246158). 37246158
FLT3 Q577_Y589delinsPSD hematologic cancer predicted - sensitive Sorafenib Preclinical - Biochemical Actionable In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation in cells expressing FLT3 Q577_Y589delinsPSD in culture (PMID: 37246158). 37246158