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Gene FLT3
Variant F590_D593delinsGP
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FLT3 F590_D593delinsGP results in a deletion of four amino acids in the juxtamembrane domain of the Flt3 protein from amino acids 590 to 593, combined with the insertion of a glycine (G) and a proline (P) at the same site (PMID: 37246158). F590_D593delinsGP results in Flt3 phosphorylation similar to wild-type Flt3 in culture (PMID: 37246158), but has not been fully biochemically characterized and therefore, its effect on Flt3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 F590_D593delinsGP

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Transcript NM_004119.2
gDNA chr13:g.28034140_28034151delinsAGGACC
cDNA c.1768_1779delinsGGTCCT
Protein p.F590_D593delinsGP
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28034140_28034151delinsAGGACC c.1768_1779delinsGGTCCT p.F590_D593delinsGP RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 F590_D593delinsGP hematologic cancer predicted - sensitive Quizartinib Preclinical - Biochemical Actionable In a preclinical study, Vanflyta (quizartinib) inhibited Flt3 phosphorylation in cells expressing FLT3 F590_D593delinsGP in culture (PMID: 37246158). 37246158
FLT3 F590_D593delinsGP hematologic cancer predicted - sensitive Sorafenib Preclinical - Biochemical Actionable In a preclinical study, Nexavar (sorafenib) inhibited Flt3 phosphorylation in cells expressing FLT3 F590_D593delinsGP in culture (PMID: 37246158). 37246158