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FLT3 Y589_D593del - Gene Variant Detail

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Gene FLT3
Variant Y589_D593del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions FLT3 Y589_D593del results in the deletion of five amino acids in the juxtamembrane domain of the Flt3 protein from amino acids 589 to 593 (PMID: 37246158). Y589_D593del results in Flt3 phosphorylation similar to wild-type Flt3 in culture (PMID: 37246158), but has not been fully biochemically characterized and therefore, its effect on Flt3 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 Y589_D593del

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Transcript NM_004119.2
gDNA chr13:g.28034140_28034154del15
cDNA c.1766_1780del15
Protein p.Y589_D593del
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.