FLT3 D835L
Gene Variant Detail

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Gene FLT3
Variant D835L
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 D835L lies within the activation loop in the protein kinase domain of the Flt3 protein (PMID: 25837374). D835L results in IL3-independent growth in culture (PMID: 28077790), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 D835L

FLT3 mutant FLT3 exon20 FLT3 D835X FLT3 D835L

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Transcript NM_004119.2
gDNA chr13:g.28018504_28018505delGAinsCT
cDNA c.2503_2504delGAinsCT
Protein p.D835L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018504_28018505delGAinsCT c.2503_2504delGAinsCT p.D835L RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References