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Gene FLT3
Variant D835K
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 D835K lies within the activation loop in the protein kinase domain of the Flt3 protein (PMID: 25837374). D835K results in IL3-independent growth in culture (PMID: 28077790), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 D835K

FLT3 mutant FLT3 exon20 FLT3 D835X FLT3 D835K

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Transcript NM_004119.2
gDNA chr13:g.28018503_28018505delGATinsAAG
cDNA c.2503_2505delGATinsAAG
Protein p.D835K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018503_28018505delGATinsAAG c.2503_2505delGATinsAAG p.D835K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References