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Gene FLT3
Variant I836D
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 I836D lies within the protein kinase domain of the Flt3 protein (UniProt.org). I836D results in IL3-independent growth in culture (PMID: 28077790), and therefore, is predicted to lead to a gain of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 I836D

FLT3 mutant FLT3 exon20 FLT3 I836X FLT3 I836D

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Transcript NM_004119.2
gDNA chr13:g.28018501_28018502delATinsGA
cDNA c.2506_2507delATinsGA
Protein p.I836D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018501_28018502delATinsGA c.2506_2507delATinsGA p.I836D RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References