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Gene | TP53 |
Variant | E258A |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 E258A lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). E258A has been identified in the scientific literature (PMID: 17786186, PMID: 32164171, PMID: 35856441), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Sep 2024). |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon7 TP53 E258A |
Transcript | NM_000546.6 |
gDNA | chr17:g.7674190T>G |
cDNA | c.773A>C |
Protein | p.E258A |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001407262.1 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001407264.1 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7674190T>G | c.773A>C | p.E258A | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
TP53 E258A | unknown |