FGFR2 C492F - Gene Variant Detail

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Gene FGFR2
Variant C492F
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 C492F (corresponds to C491F in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). C492F results in reduced Frs2 and Erk phosphorylation in the context of an FGFR2 fusion and confers resistance to FGFR inhibitors in the context of FGFR2-PHGDH in culture (PMID: 37843855), but has not been individually characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance Y
Category Variants Paths

FGFR2 mutant FGFR2 C492F

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Transcript NM_022970.4
gDNA chr10:g.121500915C>A
cDNA c.1475G>T
Protein p.C492F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_022970.4 chr10:g.121500915C>A c.1475G>T p.C492F RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121500915C>A c.1475G>T p.C492F RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References