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Gene FGFR2
Variant N550D
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 N550D (corresponds to N549D in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N550D has been identified in the scientific literature (PMID: 37843855, PMID: 39226398), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 N550D

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Transcript NM_022970.4
gDNA chr10:g.121498522T>C
cDNA c.1648A>G
Protein p.N550D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144919.2 chr10:g.121488065T>C c.1648A>G p.N550D RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121498522T>C c.1648A>G p.N550D RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121498522T>C c.1648A>G p.N550D RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121487993T>C c.1648A>G p.N550D RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries