Gene Variant Detail

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Gene TP53
Variant C238R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 C238R lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). C238R does not confer sensitivity to Tp53 activator in patient cells in culture (PMID: 16081689), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 C238R

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Transcript NM_000546.6
gDNA chr17:g.7674251A>G
cDNA c.712T>C
Protein p.C238R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001276761.3 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674251A>G c.712T>C p.C238R RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673791A>G c.712T>C p.C238R RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References