FGFR2 L634V
Gene Variant Detail

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Gene FGFR2
Variant L634V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L634V (corresponds to L633V in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L634V has been identified in the scientific literature (PMID: 37843855, PMID: 36089135), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 L634V

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Transcript NM_022970.4
gDNA chr10:g.121488080A>C
cDNA c.1900T>G
Protein p.L634V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144913.1 chr10:g.121488080A>C c.1900T>G p.L634V RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121488080A>C c.1900T>G p.L634V RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121496546A>C c.1900T>G p.L634V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR2 L634V unknown