Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@genomenon.com

Gene MLH1
Variant N64S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MLH1 N64S lies within the ATPase domain of the Mlh1 protein (PMID: 22753075). The functional effect of N64S is conflicting as it results in reduced Pms2 and Mlh1 expression in culture (PMID: 36054288, PMID: 21404117), reduced interaction with Pms2 in a yeast-two-hybrid assay (PMID: 21404117), loss of mismatch repair (MMR) activity in two of three yeast assays, reduced MMR activity in vitro (PMID: 17510385) and in culture (PMID: 17135187), and increased mutation rate in yeast assays (PMID: 17210669), but in other studies results in stabilization of Pms2 in culture (PMID: 17135187), MMR activity comparable to wild-type in culture, and demonstrates no splicing defects (PMID: 36054288).
Associated Drug Resistance
Category Variants Paths

MLH1 mutant MLH1 N64S

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_000249.4
gDNA chr3:g.36996693A>G
cDNA c.191A>G
Protein p.N64S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354629.2 chr3:g.36996693A>G c.191A>G p.N64S RefSeq GRCh38/hg38
NM_000249.4 chr3:g.36996693A>G c.191A>G p.N64S RefSeq GRCh38/hg38
NM_001258271.2 chr3:g.36996693A>G c.191A>G p.N64S RefSeq GRCh38/hg38
NM_001354630.2 chr3:g.36996693A>G c.191A>G p.N64S RefSeq GRCh38/hg38
NM_001354628.2 chr3:g.36996693A>G c.191A>G p.N64S RefSeq GRCh38/hg38
XM_005265161.3 chr3:g.36996693A>G c.191A>G p.N64S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References