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Gene FGFR3
Variant K649_K650delinsIE
Impact List indel
Protein Effect unknown
Gene Variant Descriptions FGFR3 K649_K650delinsIE results in the deletion of two amino acids in the protein kinase domain of the Fgfr3 protein from amino acids 649 to 650, combined with the insertion of an isoleucine (I) and glutamic acid (E) at the same site (UniProt.org). K649_K650delinsIE has been identified in sequencing studies (PMID: 37682528), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 K649_K650delinsIE

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Transcript NM_000142.5
gDNA chr4:g.1806159_1806164delinsATCGAG
cDNA c.1945_1950delinsATCGAG
Protein p.K649_K650delinsIE
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000142.5 chr4:g.1806159_1806164delinsATCGAG c.1945_1950delinsATCGAG p.K649_K650delinsIE RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806159_1806164delinsATCGAG c.1945_1950delinsATCGAG p.K649_K650delinsIE RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806159_1806164delinsATCGAG c.1945_1950delinsATCGAG p.K649_K650delinsIE RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806159_1806164delinsATCGAG c.1945_1950delinsATCGAG p.K649_K650delinsIE RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR3 K649_K650delinsIE unknown