FGFR2 R255W
Gene Variant Detail

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Gene FGFR2
Variant R255W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 R255W lies within the extracellular domain of the Fgfr2 protein (UniProt.org). R255W has been identified in sequencing studies (PMID: 37964396, PMID: 37682528), but has not been biochemically characterized and therefore, its effect on Fgfr3 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon7 FGFR2 R255W

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Transcript NM_000141.5
gDNA chr10:g.121520155G>A
cDNA c.763C>T
Protein p.R255W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658.2 chr10:g.121520155G>A c.763C>T p.R255W RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121520155G>A c.763C>T p.R255W RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121520155G>A c.763C>T p.R255W RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121520155G>A c.763C>T p.R255W RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121520155G>A c.763C>T p.R255W RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References