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Gene FGFR2
Variant K545del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions FGFR2 K545del results in the deletion of an amino acid in the protein kinase domain of the Fgfr2 protein at amino acid 545 (UniProt.org). K545del results in increased proliferation, migration, and invasion in 2 of 3 cell lines in culture (PMID: 37964396), and therefore, is predicted to lead to a gain of Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K545del

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Transcript NM_000141.5
gDNA chr10:g.121498532_121498534delCTT
cDNA c.1635_1637delGAA
Protein p.K545del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121498532_121498534delCTT c.1635_1637delGAA p.K545del RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 K545del cholangiocarcinoma no benefit Infigratinib Preclinical - Cell culture Actionable In a preclinical study, Truseltiq (infigratinib) did not decrease viability of a cholangiocarcinoma cell line expressing FGFR2 K545del in culture (PMID: 37964396). 37964396