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Gene PIK3CA
Variant Q859K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA Q859K lies within the PI3K/PI4K catalytic domain of the Pik3ca protein (UniProt.org). Q859K has been associated with resistance to PI3K inhibitors in culture (PMID: 37916958), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance Y
Category Variants Paths

PIK3CA mutant PIK3CA Q859K

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Transcript NM_006218.4
gDNA chr3:g.179229351C>A
cDNA c.2575C>A
Protein p.Q859K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179229351C>A c.2575C>A p.Q859K RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179229351C>A c.2575C>A p.Q859K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References