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Gene | TP53 |
Variant | P152Q |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | TP53 P152Q lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). P152Q results in interaction with Tbk1 leading to decreased Tbk1 and Irf3 phosphorylation and loss of Irf3 activation in culture (PMID: 33545063), but has not been fully biochemically characterized and therefore, its effect on Tp53 protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
TP53 mutant TP53 exon5 TP53 P152Q |
Transcript | NM_000546.6 |
gDNA | chr17:g.7675157G>T |
cDNA | c.455C>A |
Protein | p.P152Q |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001407264.1 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001407268.1 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001126113.3 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001407266.1 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001126112.3 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_000546.6 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001407270.1 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001126114.3 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
NM_001407262.1 | chr17:g.7675157G>T | c.455C>A | p.P152Q | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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