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PTEN F90Lfs*90 - Gene Variant Detail

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Gene PTEN
Variant F90Lfs*90
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN F90Lfs*90 indicates a shift in the reading frame starting at amino acid 90 and terminating 90 residues downstream causing a premature truncation of the 403 amino acid Pten protein (UniProt.org). F90Lfs*90 has not been characterized, however, due to the effects of other truncation mutations downstream of F90 (PMID: 10468583), is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN F90Lfs*90

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Transcript NM_000314.8
gDNA chr10:g.(87933027_87952165)
cDNA c.(268_540)
Protein p.F90Lfs*90
Source Database RefSeq
Genome Build GRCh38/hg38

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Sorting

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